Where have all the Orais gone? Commentary on “Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory”

• Orai1 was suggested to amplify dendritic spine Ca 2+ signals. However, Orai2 more abundant than in spines of hippocampal neurons. Roles and Orai3 neurons were not addressed. The contribution IP 3 -dependent release considered. channels reported as critical contributors the signal underlying synaptic plasticity associated with learning memory. We discuss results view conflicting other reports that stressed roles but failed detect functions these